Age-induced nitrative stress decreases retrograde transport of proNGF via TrkA and increases proNGF retrograde transport and neurodegeneration via p75NTR

Age-induced nitrative stress decreases retrograde transport of proNGF via TrkA and increases proNGF retrograde transport and neurodegeneration via p75NTR

IntroductionAxonal transport of pro nerve growth factor (proNGF) is impaired in aged basal forebrain cholinergic neurons (BFCNs), which is associated with their degeneration. ProNGF is neurotrophic in the presence of its receptor tropomyosin-related kinase A (TrkA) but induces apoptosis via the pan-...

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Bibliographic Details
Main Authors: Erika Kropf, Arman Shekari, Sama Jaberi, Anish Puri, Chengbiao Wu, Margaret Fahnestock
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-11-01
Series:Frontiers in Molecular Neuroscience
Subjects:
nitrative stress
pro nerve growth factor
basal forebrain cholinergic neurons
axonal transport
TrkA
p75NTR
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2023.1241420/full

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https://www.frontiersin.org/articles/10.3389/fnmol.2023.1241420/full

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