Sevoflurane Postconditioning Attenuates Hepatic Ischemia-Reperfusion Injury by Limiting HMGB1/TLR4/NF-κB Pathway via Modulating microRNA-142 in vivo and in vitro

Sevoflurane Postconditioning Attenuates Hepatic Ischemia-Reperfusion Injury by Limiting HMGB1/TLR4/NF-κB Pathway via Modulating microRNA-142 in vivo and in vitro

Preconditioning of sevoflurane (Sevo) has been demonstrated to protect the liver from ischemia/reperfusion (I/R) injury. However, it is unknown whether it has hepatoprotective when given at the onset of reperfusion (postconditioning), a protocol with more clinical impact. The present study aimed to...

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Bibliographic Details
Main Authors: Liying Xu, Feng Ge, Yan Hu, Ying Yu, Kefang Guo, Changhong Miao
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Pharmacology
Subjects:
hepatic ischemia-reperfusion injury
sevoflurane
postconditioning
microRNA-142
HMGB1/TLR4/NF-κB pathway
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.646307/full

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https://www.frontiersin.org/articles/10.3389/fphar.2021.646307/full

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