Group 2 Innate Lymphoid Cells Protect Mice from Abdominal Aortic Aneurysm Formation via IL5 and Eosinophils

Group 2 Innate Lymphoid Cells Protect Mice from Abdominal Aortic Aneurysm Formation via IL5 and Eosinophils

Abstract Development of abdominal aortic aneurysms (AAA) enhances lesion group‐2 innate lymphoid cell (ILC2) accumulation and blood IL5. ILC2 deficiency in Rorafl/flIl7rCre/+ mice or induced ILC2 depletion in Icosfl‐DTR‐fl/+Cd4Cre/+ mice expedites AAA growth, increases lesion inflammation, but leads...

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Bibliographic Details
Main Authors: Yuanyuan Zhang, Tianxiao Liu, Zhiyong Deng, Wenqian Fang, Xian Zhang, Shuya Zhang, Minjie Wang, Songyuan Luo, Zhaojie Meng, Jing Liu, Galina K. Sukhova, Dazhu Li, Andrew N. J. McKenzie, Peter Libby, Guo‐Ping Shi, Junli Guo
Format: Article
Language:English
Published: Wiley 2023-03-01
Series:Advanced Science
Subjects:
abdominal aortic aneurysm
eosinophil
Group‐2 innate lymphoid cell
IL5
Online Access:https://doi.org/10.1002/advs.202206958

Internet

https://doi.org/10.1002/advs.202206958

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