Prediction of Response to Cisplatin-Based Neoadjuvant Chemotherapy of Muscle-Invasive Bladder Cancer Patients by Molecular Subtyping including KRT and FGFR Target Gene Assessment

Prediction of Response to Cisplatin-Based Neoadjuvant Chemotherapy of Muscle-Invasive Bladder Cancer Patients by Molecular Subtyping including KRT and FGFR Target Gene Assessment

Patients with muscle-invasive urothelial carcinoma achieving pathological complete response (pCR) upon neoadjuvant chemotherapy (NAC) have improved prognosis. Molecular subtypes of bladder cancer differ markedly regarding sensitivity to cisplatin-based chemotherapy and harbor FGFR treatment targets...

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Bibliographic Details
Main Authors: Thorsten H. Ecke, Paula Carolin Voß, Thorsten Schlomm, Anja Rabien, Frank Friedersdorff, Dimitri Barski, Thomas Otto, Michael Waldner, Elke Veltrup, Friederike Linden, Roland Hake, Sebastian Eidt, Jenny Roggisch, Axel Heidenreich, Constantin Rieger, Lucas Kastner, Steffen Hallmann, Stefan Koch, Ralph M. Wirtz
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:International Journal of Molecular Sciences
Subjects:
bladder cancer
neoadjuvant chemotherapy
FGFR1
FGFR3
KRT5
KRT20
Online Access:https://www.mdpi.com/1422-0067/23/14/7898

Internet

https://www.mdpi.com/1422-0067/23/14/7898

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