Trimeric receptor-binding domain of SARS-CoV-2 acts as a potent inhibitor of ACE2 receptor-mediated viral entry

Trimeric receptor-binding domain of SARS-CoV-2 acts as a potent inhibitor of ACE2 receptor-mediated viral entry

Summary: The COVID-19 pandemic has caused over four million deaths and effective methods to control CoV-2 infection, in addition to vaccines, are needed. The CoV-2 binds to the ACE2 on human cells through the receptor-binding domain (RBD) of the trimeric spike protein. Our modeling studies show that...

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Bibliographic Details
Main Authors: Shrikanth C. Basavarajappa, Angela Rose Liu, Anna Bruchez, Zhenlu Li, Vinicius G. Suzart, Zhonghua Liu, Yinghua Chen, Tsan Sam Xiao, Matthias Buck, Parameswaran Ramakrishnan
Format: Article
Language:English
Published: Elsevier 2022-08-01
Series:iScience
Subjects:
Molecular structure
Virology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004222009889

Internet

http://www.sciencedirect.com/science/article/pii/S2589004222009889

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