The Role of Proteomics and Phosphoproteomics in the Discovery of Therapeutic Targets and Biomarkers in Acquired EGFR-TKI-Resistant Non-Small Cell Lung Cancer

The Role of Proteomics and Phosphoproteomics in the Discovery of Therapeutic Targets and Biomarkers in Acquired EGFR-TKI-Resistant Non-Small Cell Lung Cancer

The discovery of potent EGFR-tyrosine kinase inhibitors (EGFR-TKIs) has revolutionized the treatment of EGFR-mutated lung cancer. Despite the fact that EGFR-TKIs have yielded several significant benefits for lung cancer patients, the emergence of resistance to EGFR-TKIs has been a substantial impedi...

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Bibliographic Details
Main Authors: Sutpirat Moonmuang, Apichat Tantraworasin, Santhasiri Orrapin, Sasimol Udomruk, Busyamas Chewaskulyong, Dumnoensun Pruksakorn, Parunya Chaiyawat
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:International Journal of Molecular Sciences
Subjects:
lung cancer
non-small cell lung cancer
EGFR-TKI resistance
proteomics
phosphoproteomics
Online Access:https://www.mdpi.com/1422-0067/24/5/4827

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https://www.mdpi.com/1422-0067/24/5/4827

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