Tissue architecture delineates field cancerization in BRAFV600E-induced tumor development

Tissue architecture delineates field cancerization in BRAFV600E-induced tumor development

Cancer cells hijack developmental growth mechanisms but whether tissue morphogenesis and architecture modify tumorigenesis is unknown. Here, we characterized a new mouse model of sporadic thyroid carcinogenesis based on inducible expression of BRAF carrying a Val600 Glu (V600E) point mutation (BRAFV...

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Bibliographic Details
Main Authors: Elin Schoultz, Ellen Johansson, Carmen Moccia, Iva Jakubikova, Naveen Ravi, Shawn Liang, Therese Carlsson, Mikael Montelius, Konrad Patyra, Jukka Kero, Kajsa Paulsson, Henrik Fagman, Martin O. Bergo, Mikael Nilsson
Format: Article
Language:English
Published: The Company of Biologists 2022-02-01
Series:Disease Models & Mechanisms
Subjects:
braf mutation
cancer
development
oligoclonal
oncogenic activation
thyroid
Online Access:http://dmm.biologists.org/content/15/2/dmm048887

Internet

http://dmm.biologists.org/content/15/2/dmm048887

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