Evaluation of the Physicochemical Properties, Pharmacokinetics, and In Vitro Anticancer Effects of Docetaxel and Osthol Encapsulated in Methoxy Poly(ethylene glycol)-<i>b</i>-Poly(caprolactone) Polymeric Micelles

Evaluation of the Physicochemical Properties, Pharmacokinetics, and In Vitro Anticancer Effects of Docetaxel and Osthol Encapsulated in Methoxy Poly(ethylene glycol)-<i>b</i>-Poly(caprolactone) Polymeric Micelles

Docetaxel (DTX), a taxane-based anticancer drug, and osthol (OTH), a coumarin-derivative compound, have shown anticancer effects against different types of cancers through various mechanisms. However, these drugs have low solubility in water and low oral bioavailability, and thus their clinical appl...

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Bibliographic Details
Main Authors: Min Jeong Jo, Yu Jin Lee, Chun-Woong Park, Youn Bok Chung, Jin-Seok Kim, Mi Kyeong Lee, Dae Hwan Shin
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:International Journal of Molecular Sciences
Subjects:
docetaxel
osthol
mPEG-<i>b</i>-PCL polymeric micelles
combination therapy
pharmacokinetics
Online Access:https://www.mdpi.com/1422-0067/22/1/231

Internet

https://www.mdpi.com/1422-0067/22/1/231

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