Are mRNA based transcriptomic signatures ready for diagnosing tuberculosis in the clinic? - A review of evidence and the technological landscape

Are mRNA based transcriptomic signatures ready for diagnosing tuberculosis in the clinic? - A review of evidence and the technological landscape

Summary: Advances in discovery and validation of diagnostic, prognostic and treatment-monitoring transcriptomic signatures of tuberculosis (TB) disease could accelerate the goal to end TB. We conducted a review to evaluate whether mRNA transcriptomics technologies are sufficiently mature to develop...

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Bibliographic Details
Main Authors: Yohhei Hamada, Adam Penn-Nicholson, Sriram Krishnan, Daniela Maria Cirillo, Alberto Matteelli, Romain Wyss, Claudia M. Denkinger, Molebogeng X. Rangaka, Morten Ruhwald, Samuel G. Schumacher
Format: Article
Language:English
Published: Elsevier 2022-08-01
Series:EBioMedicine
Subjects:
Point-of-care TB diagnostics
Transcriptomics
mRNA signature
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Online Access:http://www.sciencedirect.com/science/article/pii/S2352396422003553

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http://www.sciencedirect.com/science/article/pii/S2352396422003553

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