Apabetalone Downregulates Fibrotic, Inflammatory and Calcific Processes in Renal Mesangial Cells and Patients with Renal Impairment

Apabetalone Downregulates Fibrotic, Inflammatory and Calcific Processes in Renal Mesangial Cells and Patients with Renal Impairment

Epigenetic mechanisms are implicated in transcriptional programs driving chronic kidney disease (CKD). Apabetalone is an orally available inhibitor of bromodomain and extraterminal (BET) proteins, which are epigenetic readers that modulate gene expression. In the phase 3 BETonMACE trial, apabetalone...

Full description

Bibliographic Details
Main Authors: Dean Gilham, Sylwia Wasiak, Brooke D. Rakai, Li Fu, Laura M. Tsujikawa, Christopher D. Sarsons, Agostina Carestia, Kenneth Lebioda, Jan O. Johansson, Michael Sweeney, Kamyar Kalantar-Zadeh, Ewelina Kulikowski
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:Biomedicines
Subjects:
chronic kidney disease (CKD)
fibrosis
inflammation
gene expression
epigenetics
BET proteins
Online Access:https://www.mdpi.com/2227-9059/11/6/1663

Internet

https://www.mdpi.com/2227-9059/11/6/1663

Similar Items