Apabetalone Downregulates Fibrotic, Inflammatory and Calcific Processes in Renal Mesangial Cells and Patients with Renal Impairment

Apabetalone Downregulates Fibrotic, Inflammatory and Calcific Processes in Renal Mesangial Cells and Patients with Renal Impairment

Epigenetic mechanisms are implicated in transcriptional programs driving chronic kidney disease (CKD). Apabetalone is an orally available inhibitor of bromodomain and extraterminal (BET) proteins, which are epigenetic readers that modulate gene expression. In the phase 3 BETonMACE trial, apabetalone...

Full description

Bibliographic Details
Main Authors:	Dean Gilham, Sylwia Wasiak, Brooke D. Rakai, Li Fu, Laura M. Tsujikawa, Christopher D. Sarsons, Agostina Carestia, Kenneth Lebioda, Jan O. Johansson, Michael Sweeney, Kamyar Kalantar-Zadeh, Ewelina Kulikowski
Format:	Article
Language:	English
Published:	MDPI AG 2023-06-01
Series:	Biomedicines
Subjects:	chronic kidney disease (CKD) fibrosis inflammation gene expression epigenetics BET proteins
Online Access:	https://www.mdpi.com/2227-9059/11/6/1663

Similar Items

Apabetalone, a Clinical-Stage, Selective BET Inhibitor, Opposes DUX4 Target Gene Expression in Primary Human FSHD Muscle Cells
by: Christopher D. Sarsons, et al.
Published: (2023-09-01)

The BET inhibitor apabetalone decreases neuroendothelial proinflammatory activation in vitro and in a mouse model of systemic inflammation
by: Wasiak Sylwia, et al.
Published: (2023-12-01)

Bromodomain and Extraterminal Protein Inhibitor, Apabetalone (RVX-208), Reduces ACE2 Expression and Attenuates SARS-Cov-2 Infection In Vitro
by: Dean Gilham, et al.
Published: (2021-04-01)

Apabetalone Mediated Epigenetic Modulation is Associated with Favorable Kidney Function and Alkaline Phosphatase Profile in Patients with Chronic Kidney Disease
by: Ewelina Kulikowski, et al.
Published: (2018-03-01)

Inhibition of epigenetic reader proteins by apabetalone counters inflammation in activated innate immune cells from Fabry disease patients receiving enzyme replacement therapy
by: Li Fu, et al.
Published: (2022-06-01)

Understanding the Renal Fibrotic Process in Leptospirosis
by: Luan Gavião Prado, et al.
Published: (2021-10-01)

Data on gene and protein expression changes induced by apabetalone (RVX-208) in ex vivo treated human whole blood and primary hepatocytes
by: Sylwia Wasiak, et al.
Published: (2016-09-01)

Presa in carico infermieristica nella Malattia Renale Cronica
by: Maria Pia Zito, et al.
Published: (2021-09-01)

Renal resistive index in non-alcoholic fatty liver disease as an indicator of early renal affection
by: Hossam El-Din A. Mahmoud, et al.
Published: (2020-02-01)

Reduction in the risk of major adverse cardiovascular events with the BET protein inhibitor apabetalone in patients with recent acute coronary syndrome, type 2 diabetes, and moderate to high likelihood of non-alcoholic fatty liver disease
by: Peter P. Toth, et al.
Published: (2022-09-01)

Echocardiographic Changes in Patients with End-Stage Renal Disease at Initiation of Dialysis
by: Shabana Nazneen, et al.
Published: (2021-06-01)

Echocardiographic Changes in Patients with End-Stage Renal Disease at Initiation of Dialysis
by: Shabana Nazneen, et al.
Published: (2021-06-01)

RENAL AFFECTATION IN POLYRHEUMATOID ARTHRITIS
by: Delia Timofte, et al.
Published: (2019-06-01)

Epidemiología y tratamiento de la anemia renal en España: estudio retrospectivo RIKAS
by: Aleix Cases, et al.
Published: (2023-09-01)

Clinical Significance of Adropin and Afamin in Evaluating Renal Function and Cardiovascular Health in the Presence of CKD-MBD Biomarkers in Chronic Kidney Disease
by: Rupinder Kaur, et al.
Published: (2023-10-01)

RATING SCORE SPECIALIZED MEDICAL CARE PATIENTS RENAL PROFILE IN UKRAINE 2016
by: M. O. Kolesnyk, et al.
Published: (2017-06-01)

Hematuria as a risk factor for progression of chronic kidney disease and death: findings from the Chronic Renal Insufficiency Cohort (CRIC) Study
by: Paula F. Orlandi, et al.
Published: (2018-06-01)

Effect of hyperglycemia and rosiglitazone on renal and urinary neprilysin in db/db diabetic mice
by: Laale F. Alawi, et al.
Published: (2020-02-01)

Cardiovascular and renal burdens among patients with MAFLD and NAFLD in China
by: Yuying Wang, et al.
Published: (2022-09-01)

Sirtuins and Renal Oxidative Stress
by: Yoshio Ogura, et al.
Published: (2021-07-01)

Assessment of puberty in children with chronic kidney disease and end-stage renal disease undergoing hemodialysis
by: Emad E. Ghobrial, et al.
Published: (2022-12-01)

Clinical-immunological parallels in chronic renal Failure in children
by: G. A. Makovetskaya, et al.
Published: (2023-03-01)

Gum Arabic in renal disease (GARDS Study): Clinical evidence of dietary supplementation impact on progression of renal dysfunction
by: Sami A. Khalid, et al.
Published: (2021-07-01)

Risk factors and implications associated with renal mineralization in chronic kidney disease in cats
by: Pak‐Kan Tang, et al.
Published: (2022-03-01)

Tanshinone I attenuates fibrosis in fibrotic kidneys through down-regulation of inhibin beta-A
by: Ming Wu, et al.
Published: (2022-04-01)

Are Sports Bettors Biased toward Longshots, Favorites, or Both? A Literature Review
by: Philip W. S. Newall, et al.
Published: (2021-01-01)

Placental and Renal Pathways Underlying Pre-Eclampsia
by: Paraskevi Eva Andronikidi, et al.
Published: (2024-02-01)

Gender and sex in the development and progression of renal diseases
by: Marcora Mandreoli
Published: (2023-09-01)

Renal Rehabilitation—Its Theory and Clinical Application to Patients Undergoing Daily Dialysis Therapy
by: Ryota Matsuzawa, et al.
Published: (2022-11-01)

Salvianolic Acid C Inhibits the Epithelial-Mesenchymal Transition and Ameliorates Renal Tubulointerstitial Fibrosis
by: Ming Wu, et al.
Published: (2023-06-01)

Nicotinamide Attenuates the Progression of Renal Failure in a Mouse Model of Adenine-Induced Chronic Kidney Disease
by: Satoshi Kumakura, et al.
Published: (2021-01-01)

Concordance between modification of diet in renal disease, chronic kidney disease epidemiology collaboration and Cockcroft-Gault equations in patients with chronic kidney disease at St. Paul’s hospital millennium medical college, Addis Ababa, Ethiopia
by: Hunduma Dinsa, et al.
Published: (2017-12-01)

The effect of renal diet in association with enalapril or benazepril on proteinuria in dogs with proteinuric chronic kidney disease
by: A. Zatelli, et al.
Published: (2016-07-01)

Renal asymmetric dimethylarginine inhibits fibrosis
by: Ming Wu, et al.
Published: (2020-10-01)

DWI as a biomarker of renal function in children with CKD: what is the potential?
by: Sally Emad-Eldin, et al.
Published: (2020-08-01)

Therapeutic efficacy of pentoxifylline on proteinuria and renal progression: an update
by: Yung-Ming Chen, et al.
Published: (2017-11-01)

Hedging on Betting Markets
by: Gustav Axén, et al.
Published: (2020-08-01)

Characterisation of feline renal cortical fibroblast cultures and their transcriptional response to transforming growth factor β1
by: J. S. Lawson, et al.
Published: (2018-03-01)

Effects of tolvaptan on renal function in chronic kidney disease patients with volume overload
by: Suzuki S, et al.
Published: (2018-08-01)

Evaluation of renal function in clinical practice: the basics
by: Alessia Casola, et al.
Published: (2019-03-01)