Chemistry and Hypoglycemic Activity of GPR119 Agonist ZB-16

Chemistry and Hypoglycemic Activity of GPR119 Agonist ZB-16

This article is to highlight the chemical properties and primary pharmacology of novel GPR119 agonist ZB-16 and its analogs, which were rejected during the screening. Experiments were performed in vitro (specific activity, metabolism and cell toxicity) and in vivo (hypoglycemic activity and pharmaco...

Full description

Bibliographic Details
Main Authors: Ivan N. Tyurenkov, Denis V. Kurkin, Dmitry A. Bakulin, Elena V. Volotova, Evgeny I. Morkovin, Mikhail A. Chafeev, Ruben N. Karapetian
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Endocrinology
Subjects:
ZB-16
sitagliptin
T2D
hypoglycemia
GPR119 agonists
rats
Online Access:https://www.frontiersin.org/article/10.3389/fendo.2018.00543/full

Internet

https://www.frontiersin.org/article/10.3389/fendo.2018.00543/full

Similar Items