Chemistry and Hypoglycemic Activity of GPR119 Agonist ZB-16

Chemistry and Hypoglycemic Activity of GPR119 Agonist ZB-16

This article is to highlight the chemical properties and primary pharmacology of novel GPR119 agonist ZB-16 and its analogs, which were rejected during the screening. Experiments were performed in vitro (specific activity, metabolism and cell toxicity) and in vivo (hypoglycemic activity and pharmaco...

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Bibliographic Details
Main Authors: Ivan N. Tyurenkov, Denis V. Kurkin, Dmitry A. Bakulin, Elena V. Volotova, Evgeny I. Morkovin, Mikhail A. Chafeev, Ruben N. Karapetian
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Endocrinology
Subjects:
ZB-16
sitagliptin
T2D
hypoglycemia
GPR119 agonists
rats
Online Access:https://www.frontiersin.org/article/10.3389/fendo.2018.00543/full

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