Study of the sensitivity and specificity of smell and taste disorders as a predictive factor of SARS-CoV-2 infection among primary care healthcare professionals: a retrospective observational study
Background: Among the manifestations of COVID-19 are taste and smell disorders (TSDs). Aim: To evaluate the sensitivity and specificity of TSDs and other associated symptoms to estimate predictive values for determining SARS-CoV-2 infection. Design & setting: A retrospective observational study...
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| Format: | Article |
| Language: | English |
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Royal College of General Practitioners
2022-06-01
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| Series: | BJGP Open |
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| Online Access: | https://bjgpopen.org/content/6/2/BJGPO.2021.0141 |
| _version_ | 1828418205215883264 |
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| author | Anna Ruiz-Comellas Pere Roura Poch Glòria Sauch Valmaña Víctor Guadalupe-Fernández Jacobo Mendioroz Peña Queralt Miró Catalina Josep Vidal-Alaball Anna Ramirez-Morros |
| author_facet | Anna Ruiz-Comellas Pere Roura Poch Glòria Sauch Valmaña Víctor Guadalupe-Fernández Jacobo Mendioroz Peña Queralt Miró Catalina Josep Vidal-Alaball Anna Ramirez-Morros |
| author_sort | Anna Ruiz-Comellas |
| collection | DOAJ |
| description | Background: Among the manifestations of COVID-19 are taste and smell disorders (TSDs). Aim: To evaluate the sensitivity and specificity of TSDs and other associated symptoms to estimate predictive values for determining SARS-CoV-2 infection. Design & setting: A retrospective observational study of healthcare professionals in Catalonia, Spain. Method: A study of the sensitivity and specificity of TSDs has been carried out using the polymerase chain reaction (PCR) test for the diagnosis of SARS-CoV-2 as the gold standard value. Logistic regressions adjusted for age and sex were performed to identify additional symptoms that might be associated with COVID-19. Results: The results are based on 226 healthcare workers with clinical symptoms suggestive of COVID-19, 116 with positive PCR and 110 with negative PCR. TSDs had an odds ratio (OR) of 12.4 (95% confidence interval [CI] = 6.3 to 26.2), sensitivity 60.3% and specificity 89.1%. In the logistic regression model, the association of TSD, fever or low-grade fever, shivering, dyspnoea, arthralgia, and myalgia obtained an area under the curve (AUC) of 85.7% (95% CI = 80.7 % to 90.7 %), sensitivity 82.8 %, specificity 80.0%, and positive predictive values 81.4% and negative 81.5%. Conclusion: TSDs are a strong predictor of COVID-19. The association of TSD, fever, low-grade fever or shivering, dyspnoea, arthralgia, and myalgia correctly predicts 85.7% of the results of the COVID-19 test. |
| first_indexed | 2024-12-10T14:33:23Z |
| format | Article |
| id | doaj.art-509875ddb02d412bb3287c1047c1b636 |
| institution | Directory Open Access Journal |
| issn | 2398-3795 |
| language | English |
| last_indexed | 2024-12-10T14:33:23Z |
| publishDate | 2022-06-01 |
| publisher | Royal College of General Practitioners |
| record_format | Article |
| series | BJGP Open |
| spelling | doaj.art-509875ddb02d412bb3287c1047c1b6362022-12-22T01:44:53ZengRoyal College of General PractitionersBJGP Open2398-37952022-06-016210.3399/BJGPO.2021.0141Study of the sensitivity and specificity of smell and taste disorders as a predictive factor of SARS-CoV-2 infection among primary care healthcare professionals: a retrospective observational studyAnna Ruiz-Comellas0Pere Roura Poch1Glòria Sauch Valmaña2Víctor Guadalupe-Fernández3Jacobo Mendioroz Peña4Queralt Miró Catalina5Josep Vidal-Alaball6Anna Ramirez-Morros7Centre d'Atenció Primària (CAP) Sant Joan de Vilatorrada. Gerència Territorial de la Catalunya Central, Institut Català de la Salut, Sant Fruitós de Bages, SpainUnitat de Suport a la Recerca de la Catalunya Central, Fundació Institut Universitari per a la Recerca a l’Atenció Primària de Salut Jordi Gol i Gurina, Barcelona, SpainHealth Promotion in Rural Areas Research Group, Institut Català de la Salut, Sant Fruitós de Bages, SpainEpidemiological Surveillance and Response to Public Health Emergencies Service, Public Health Agency of Catalonia, Barcelona, SpainEpidemiological Surveillance and Response to Public Health Emergencies Service, Public Health Agency of Catalonia, Barcelona, SpainUnitat de Suport a la Recerca de la Catalunya Central, Fundació Institut Universitari per a la Recerca a l’Atenció Primària de Salut Jordi Gol i Gurina, Barcelona, SpainHealth Promotion in Rural Areas Research Group, Institut Català de la Salut, Sant Fruitós de Bages, SpainUnitat de Suport a la Recerca de la Catalunya Central, Fundació Institut Universitari per a la Recerca a l’Atenció Primària de Salut Jordi Gol i Gurina, Barcelona, SpainBackground: Among the manifestations of COVID-19 are taste and smell disorders (TSDs). Aim: To evaluate the sensitivity and specificity of TSDs and other associated symptoms to estimate predictive values for determining SARS-CoV-2 infection. Design & setting: A retrospective observational study of healthcare professionals in Catalonia, Spain. Method: A study of the sensitivity and specificity of TSDs has been carried out using the polymerase chain reaction (PCR) test for the diagnosis of SARS-CoV-2 as the gold standard value. Logistic regressions adjusted for age and sex were performed to identify additional symptoms that might be associated with COVID-19. Results: The results are based on 226 healthcare workers with clinical symptoms suggestive of COVID-19, 116 with positive PCR and 110 with negative PCR. TSDs had an odds ratio (OR) of 12.4 (95% confidence interval [CI] = 6.3 to 26.2), sensitivity 60.3% and specificity 89.1%. In the logistic regression model, the association of TSD, fever or low-grade fever, shivering, dyspnoea, arthralgia, and myalgia obtained an area under the curve (AUC) of 85.7% (95% CI = 80.7 % to 90.7 %), sensitivity 82.8 %, specificity 80.0%, and positive predictive values 81.4% and negative 81.5%. Conclusion: TSDs are a strong predictor of COVID-19. The association of TSD, fever, low-grade fever or shivering, dyspnoea, arthralgia, and myalgia correctly predicts 85.7% of the results of the COVID-19 test.https://bjgpopen.org/content/6/2/BJGPO.2021.0141covid-19change in sense of tastechange in sense of smellsensitivity and specificityprimary health caregeneral practice |
| spellingShingle | Anna Ruiz-Comellas Pere Roura Poch Glòria Sauch Valmaña Víctor Guadalupe-Fernández Jacobo Mendioroz Peña Queralt Miró Catalina Josep Vidal-Alaball Anna Ramirez-Morros Study of the sensitivity and specificity of smell and taste disorders as a predictive factor of SARS-CoV-2 infection among primary care healthcare professionals: a retrospective observational study BJGP Open covid-19 change in sense of taste change in sense of smell sensitivity and specificity primary health care general practice |
| title | Study of the sensitivity and specificity of smell and taste disorders as a predictive factor of SARS-CoV-2 infection among primary care healthcare professionals: a retrospective observational study |
| title_full | Study of the sensitivity and specificity of smell and taste disorders as a predictive factor of SARS-CoV-2 infection among primary care healthcare professionals: a retrospective observational study |
| title_fullStr | Study of the sensitivity and specificity of smell and taste disorders as a predictive factor of SARS-CoV-2 infection among primary care healthcare professionals: a retrospective observational study |
| title_full_unstemmed | Study of the sensitivity and specificity of smell and taste disorders as a predictive factor of SARS-CoV-2 infection among primary care healthcare professionals: a retrospective observational study |
| title_short | Study of the sensitivity and specificity of smell and taste disorders as a predictive factor of SARS-CoV-2 infection among primary care healthcare professionals: a retrospective observational study |
| title_sort | study of the sensitivity and specificity of smell and taste disorders as a predictive factor of sars cov 2 infection among primary care healthcare professionals a retrospective observational study |
| topic | covid-19 change in sense of taste change in sense of smell sensitivity and specificity primary health care general practice |
| url | https://bjgpopen.org/content/6/2/BJGPO.2021.0141 |
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