Properdin oligomers adopt rigid extended conformations supporting function

Properdin oligomers adopt rigid extended conformations supporting function

Properdin stabilizes convertases formed upon activation of the complement cascade within the immune system. The biological activity of properdin depends on the oligomerization state, but whether properdin oligomers are rigid and how their structure links to function remains unknown. We show by combi...

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Bibliographic Details
Main Authors: Dennis V Pedersen, Martin Nors Pedersen, Sofia MM Mazarakis, Yong Wang, Kresten Lindorff-Larsen, Lise Arleth, Gregers R Andersen
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-01-01
Series:eLife
Subjects:
SAXS
electron microscopy
MD simulation
complement
protease
Online Access:https://elifesciences.org/articles/63356

Internet

https://elifesciences.org/articles/63356

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