A Working Hypothesis Regarding Identical Pathomechanisms between Clinical Efficacy and Adverse Reaction of Clozapine via the Activation of Connexin43

A Working Hypothesis Regarding Identical Pathomechanisms between Clinical Efficacy and Adverse Reaction of Clozapine via the Activation of Connexin43

Clozapine (CLZ) is an approved antipsychotic agent for the medication of treatment-resistant schizophrenia but is also well known as one of the most toxic antipsychotics. Recently, the World Health Organization’s (WHO) global database (VigiBase) reported the relative lethality of severe adverse reac...

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Bibliographic Details
Main Authors: Motohiro Okada, Kouji Fukuyama, Takashi Shiroyama, Masahiko Murata
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:International Journal of Molecular Sciences
Subjects:
clozapine
adverse drug reaction
schizophrenia
connexin
protein kinase B
Online Access:https://www.mdpi.com/1422-0067/21/19/7019

Internet

https://www.mdpi.com/1422-0067/21/19/7019

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