Chronic nSMase inhibition suppresses neuronal exosome spreading and sex-specifically attenuates amyloid pathology in APP knock-in Alzheimer's disease mice

Chronic nSMase inhibition suppresses neuronal exosome spreading and sex-specifically attenuates amyloid pathology in APP knock-in Alzheimer's disease mice

Female biased pathology and cognitive decline in Alzheimer's disease (AD) have been consistently observed with unclear underlying mechanisms. Although brain sphingolipid ceramide is elevated in AD patients, whether and how ceramide may contribute to sex-specific differences in amyloid pathology...

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Bibliographic Details
Main Authors: Francesca E. Mowry, Francisco Espejo-Porras, Shijie Jin, Zainuddin Quadri, Limin Wu, Marcela Bertolio, Rachel Jarvis, Caroline Reynolds, Rashed Alananzeh, Erhard Bieberich, Yongjie Yang
Format: Article
Language:English
Published: Elsevier 2023-08-01
Series:Neurobiology of Disease
Subjects:
Alzheimer's disease
nSMase
Ceramide
Exosome
Sex
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996123002280

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http://www.sciencedirect.com/science/article/pii/S0969996123002280

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