The MDM-2 Antagonist Nutlin-3 Promotes the Maturation of Acute Myeloid Leukemic Blasts

The MDM-2 Antagonist Nutlin-3 Promotes the Maturation of Acute Myeloid Leukemic Blasts

The small-molecule inhibitor of murine double minute (MDM-2), Nutlin-3, induced variable apoptosis in primary acute myeloid leukemia (AML) blasts, promoted myeloid maturation of surviving cells, as demonstrated by analysis of CD11 b, CD14 surface antigens, by morphologic examination. Although the be...

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Bibliographic Details
Main Authors: Paola Secchiero, Carlotta Zerbinati, Elisabetta Melloni, Daniela Milani, Diana Campioni, Roberto Fadda, Mario Tiribelli, Giorgio Zauli
Format: Article
Language:English
Published: Elsevier 2007-10-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
Acute myeloid leukemia
p53 pathway
surface antigens
HL-60 cells
apoptosis
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558607800650

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http://www.sciencedirect.com/science/article/pii/S1476558607800650

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