CD8+ T Cells from Mice Transnuclear for a TCR that Recognizes a Single H-2Kb-Restricted MHV68 Epitope Derived from gB-ORF8 Help Control Infection
To study the CD8+ T cell response against a mouse γ-herpes virus, we generated Kb-MHV-68-ORF8604–612RAG−/− CD8+ T cell receptor transnuclear (TN) mice as a source of virus-specific CD8+ T cells. Kb-ORF8-Tet+ CD8+ T cells, expanded in the course of a resolving MHV-68 infection, served as a source of...
Main Authors: | , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2012-05-01
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Series: | Cell Reports |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124712000940 |