Computational modeling of pancreatic cancer patients receiving FOLFIRINOX and gemcitabine-based therapies identifies optimum intervention strategies.

Computational modeling of pancreatic cancer patients receiving FOLFIRINOX and gemcitabine-based therapies identifies optimum intervention strategies.

Pancreatic ductal adenocarcinoma (PDAC) exhibits a variety of phenotypes with regard to disease progression and treatment response. This variability complicates clinical decision-making despite the improvement of survival due to the recent introduction of FOLFIRINOX (FFX) and nab-paclitaxel. Questio...

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Bibliographic Details
Main Authors: Kimiyo N Yamamoto, Akira Nakamura, Lin L Liu, Shayna Stein, Angela C Tramontano, Uri Kartoun, Tetsunosuke Shimizu, Yoshihiro Inoue, Mitsuhiro Asakuma, Hiroshi Haeno, Chung Yin Kong, Kazuhisa Uchiyama, Mithat Gonen, Chin Hur, Franziska Michor
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0215409

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https://doi.org/10.1371/journal.pone.0215409

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