The synthetic α-bromo-2',3,4,4'-tetramethoxychalcone (α-Br-TMC) inhibits the JAK/STAT signaling pathway.

The synthetic α-bromo-2',3,4,4'-tetramethoxychalcone (α-Br-TMC) inhibits the JAK/STAT signaling pathway.

Signal transducer and activator of transcription STAT5 and its upstream activating kinase JAK2 are essential mediators of cytokine signaling. Their activity is normally tightly regulated and transient. However, constitutive activation of STAT5 is found in numerous cancers and a driving force for mal...

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Bibliographic Details
Main Authors: Sophia Pinz, Samy Unser, Susanne Brueggemann, Elisabeth Besl, Nafisah Al-Rifai, Hermina Petkes, Sabine Amslinger, Anne Rascle
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0090275&type=printable

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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0090275&type=printable

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