Ortho-nitrobenzyl derivatives as potential anti-schistosomal agents

Ortho-nitrobenzyl derivatives as potential anti-schistosomal agents

ABSTRACT In the search for new anti-schistosomal agents, a series of fifteen ortho-nitrobenzyl derivatives was assayed in vitro against both the schistosomulum (somule) and adult forms of Schistosoma mansoni. Compounds 8 and 12 showed significant activity against somules at low micromolar concentrat...

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Bibliographic Details
Main Authors: Marcela Silva Lopes, Brian Michio Suzuki, Glaécia Aparecida do Nascimento Pereira, Alexandra Christina Probst, Rafaela Salgado Ferreira, Júlia Teixeira de Oliveira, Kimberly Brito Tecchio, Fabio Vieira dos Santos, Conor Robert Caffrey, Renata Barbosa de Oliveira
Format: Article
Language:English
Published: Universidade de São Paulo 2018-07-01
Series:Brazilian Journal of Pharmaceutical Sciences
Subjects:
Nitro-aromatic
Schistosoma mansoni/ anti-schistosomal activity
Cathepsin B1
Mutagenicity
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502018000200613&lng=en&tlng=en

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502018000200613&lng=en&tlng=en

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