(5-Hydroxy-4-oxo-2-styryl-4<i>H</i>-pyridin-1-yl)-acetic Acid Derivatives as Multifunctional Aldose Reductase Inhibitors

(5-Hydroxy-4-oxo-2-styryl-4<i>H</i>-pyridin-1-yl)-acetic Acid Derivatives as Multifunctional Aldose Reductase Inhibitors

As rate-limited enzyme of polyol pathway, aldose reductase (ALR2) is one of the key inhibitory targets for alleviating diabetic complications. To reduce the toxic side effects of the inhibitors and to decrease the level of oxidative stress, the inhibitory selectivity towards ALR2 against detoxicatin...

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Bibliographic Details
Main Authors: Huan Chen, Xin Zhang, Xiaonan Zhang, Wenchao Liu, Yanqi Lei, Changjin Zhu, Bing Ma
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Molecules
Subjects:
aldose reductase inhibitors
antioxidant activity
pyridinones derivatives
molecular docking
Online Access:https://www.mdpi.com/1420-3049/25/21/5135

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https://www.mdpi.com/1420-3049/25/21/5135

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