(5-Hydroxy-4-oxo-2-styryl-4<i>H</i>-pyridin-1-yl)-acetic Acid Derivatives as Multifunctional Aldose Reductase Inhibitors
As rate-limited enzyme of polyol pathway, aldose reductase (ALR2) is one of the key inhibitory targets for alleviating diabetic complications. To reduce the toxic side effects of the inhibitors and to decrease the level of oxidative stress, the inhibitory selectivity towards ALR2 against detoxicatin...
Main Authors: | Huan Chen, Xin Zhang, Xiaonan Zhang, Wenchao Liu, Yanqi Lei, Changjin Zhu, Bing Ma |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2020-11-01
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Series: | Molecules |
Subjects: | |
Online Access: | https://www.mdpi.com/1420-3049/25/21/5135 |
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