Discovery of Novel Tetrahydro-β-carboline Containing Aminopeptidase N Inhibitors as Cancer Chemosensitizers

Discovery of Novel Tetrahydro-β-carboline Containing Aminopeptidase N Inhibitors as Cancer Chemosensitizers

Aminopeptidase N (APN, CD13) is closely associated with the development and progression of cancer. Previous studies suggested APN as a biomarker for cancer stem cells. APN inhibitors have been intensively evaluated as chemosensitizers for cancer treatments. In the present study, tetrahydro-β-carboli...

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Bibliographic Details
Main Authors: Xiaoyan Xing, Fahui Li, Yajie Hu, Lin Zhang, Qian Hui, Hongyu Qin, Qixiao Jiang, Wenyan Jiang, Chunyan Fang, Lei Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Oncology
Subjects:
aminopeptidase N
inhibitor
cancer
chemosensitizer
tetrahydro-β-carboline
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.894842/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2022.894842/full

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