Dissecting the Impact of Vascular Smooth Muscle Cell ABCA1 versus ABCG1 Expression on Cholesterol Efflux and Macrophage-like Cell Transdifferentiation: The Role of SR-BI

Dissecting the Impact of Vascular Smooth Muscle Cell ABCA1 versus ABCG1 Expression on Cholesterol Efflux and Macrophage-like Cell Transdifferentiation: The Role of SR-BI

Cholesterol-laden macrophages are recognized as a major contributor to atherosclerosis. However, recent evidence indicates that vascular smooth muscle cells (VSMC) that accumulate cholesterol and transdifferentiate into a macrophage-like cell (MLC) phenotype also play a role in atherosclerosis. Ther...

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Bibliographic Details
Main Authors: Olanrewaju Oladosu, Ikechukwu C. Esobi, Rhonda R. Powell, Terri Bruce, Alexis Stamatikos
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:Journal of Cardiovascular Development and Disease
Subjects:
atherosclerosis
dedifferentiation
lipid
lipoprotein
reverse cholesterol transport
Online Access:https://www.mdpi.com/2308-3425/10/10/416

Internet

https://www.mdpi.com/2308-3425/10/10/416

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