Metformin-induced AMPK activation promotes cisplatin resistance through PINK1/Parkin dependent mitophagy in gastric cancer

Metformin-induced AMPK activation promotes cisplatin resistance through PINK1/Parkin dependent mitophagy in gastric cancer

Gastric cancer (GC) is one of the most common tumors worldwide, and cisplatin is a standard chemotherapeutic reagent for GC treatment. However, chemoresistance is an inherent challenge which limits its application and effectiveness in clinic. This study aims to investigate the mechanism of metformin...

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Bibliographic Details
Main Authors: Yi-Yi Xiao, Jin-Xing Xiao, Xiao-Yu Wang, Tao Wang, Xin-Hui Qu, Li-Ping Jiang, Fang-Fang Tou, Zhi-Ping Chen, Xiao-Jian Han
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Oncology
Subjects:
cisplatin resistance
AMPK
mitophagy
gastric cancer
metformin
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.956190/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2022.956190/full

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