Monocarboxylate transporter upregulation in induced regulatory T cells promotes resistance to anti-PD-1 therapy in hepatocellular carcinoma patients

Monocarboxylate transporter upregulation in induced regulatory T cells promotes resistance to anti-PD-1 therapy in hepatocellular carcinoma patients

BackgroundProgrammed cell death-1 (PD-1) immune checkpoint inhibitors are not effective in treating all patients with hepatocellular carcinoma (HCC), and regulatory T cells (Tregs) may determine the resistance to anti-PD-1 therapy.MethodsPatients were divided into two groups based on the clinical ef...

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Bibliographic Details
Main Authors: Jinren Zhou, Qing Shao, Yunjie Lu, Yu Li, Zibo Xu, Bo Zhou, Qiuyang Chen, Xiangyu Li, Xiaozhang Xu, Yufeng Pan, Zhenhua Deng, Yiming Wang, Yue Yu, Jian Gu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Oncology
Subjects:
hepatocellular carcinoma
monocarboxylate transporter
lactate
regulatory T cells
treatment resistance
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.960066/full

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https://www.frontiersin.org/articles/10.3389/fonc.2022.960066/full

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