PPARγ activation inhibits PDGF-induced pulmonary artery smooth muscle cell proliferation and migration by modulating TERT

PPARγ activation inhibits PDGF-induced pulmonary artery smooth muscle cell proliferation and migration by modulating TERT

Vascular remodeling is a significant feature of pulmonary artery hypertension (PAH), and is characterized by abnormal proliferation and migration of pulmonary arterial smooth muscle cells (PASMCs). Telomerase reverse transcriptase (TERT), as a determining factor for controlling telomerase activity,...

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Bibliographic Details
Main Authors: Qianqian Zhang, Wei Feng, Qingting Wang, Jian Wang, Limin Chai, Yuqian Chen, Yan Wang, Jin Liu, Manxiang Li, Xinming Xie
Format: Article
Language:English
Published: Elsevier 2022-08-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Pulmonary artery hypertension
Telomerase
Telomerase reverse transcriptase
Peroxisome proliferator-activated receptor γ
Cell proliferation
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332222006229

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http://www.sciencedirect.com/science/article/pii/S0753332222006229

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