Regulation of gene expression in hepatic cells by the mammalian Target of Rapamycin (mTOR).

Regulation of gene expression in hepatic cells by the mammalian Target of Rapamycin (mTOR).

We investigated mTOR regulation of gene expression by studying rapamycin effect in two hepatic cell lines, the non-tumorigenic WB-F344 cells and the tumorigenic WB311 cells. The latter are resistant to the growth inhibitory effects of rapamycin, thus providing us with an opportunity to study the gen...

Full description

Bibliographic Details
Main Authors: Rosa H Jimenez, Ju-Seog Lee, Mirko Francesconi, Gastone Castellani, Nicola Neretti, Jennifer A Sanders, John Sedivy, Philip A Gruppuso
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-02-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2816708?pdf=render

Internet

http://europepmc.org/articles/PMC2816708?pdf=render

Similar Items