Wild-type C-Raf gene dosage and dimerization drive prostate cancer metastasis

Wild-type C-Raf gene dosage and dimerization drive prostate cancer metastasis

Summary: Mutated Ras and Raf kinases are well-known to promote cancer metastasis via flux through the Ras/Raf/MEK/ERK (mitogen-activated protein kinase [MAPK]) pathway. A role for non-mutated Raf in metastasis is also emerging, but the key mechanisms remain unclear. Elevated expression of any of the...

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Bibliographic Details
Main Authors: Lisa Ta, Brandon L. Tsai, Weixian Deng, Jihui Sha, Grigor Varuzhanyan, Wendy Tran, James A. Wohlschlegel, Janai R. Carr-Ascher, Owen N. Witte
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:iScience
Subjects:
Biochemistry
Molecular biology
Cancer
Proteomics
Transcriptomics
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223025579

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http://www.sciencedirect.com/science/article/pii/S2589004223025579

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