Tgif1-deficiency impairs cytoskeletal architecture in osteoblasts by activating PAK3 signaling

Tgif1-deficiency impairs cytoskeletal architecture in osteoblasts by activating PAK3 signaling

Osteoblast adherence to bone surfaces is important for remodeling bone tissue. This study demonstrates that deficiency of TG-interacting factor 1 (Tgif1) in osteoblasts results in altered cell morphology, reduced adherence to collagen type I-coated surfaces, and impaired migration capacity. Tgif1 is...

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Bibliographic Details
Main Authors: Simona Bolamperti, Hiroaki Saito, Sarah Heerdmann, Eric Hesse, Hanna Taipaleenmäki
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2024-04-01
Series:eLife
Subjects:
osteoblast spreading
bone regeneration
Tgif1
PAK3
PTH
Online Access:https://elifesciences.org/articles/94265

Internet

https://elifesciences.org/articles/94265

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