Transcriptomic signatures reveal a shift towards an anti-inflammatory gene expression profile but also the induction of type I and type II interferon signaling networks through aryl hydrocarbon receptor activation in murine macrophages

Transcriptomic signatures reveal a shift towards an anti-inflammatory gene expression profile but also the induction of type I and type II interferon signaling networks through aryl hydrocarbon receptor activation in murine macrophages

IntroductionThe aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that regulates a broad range of target genes involved in the xenobiotic response, cell cycle control and circadian rhythm. AhR is constitutively expressed in macrophages (Mϕ), acting as key regulator of cytoki...

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Bibliographic Details
Main Authors: Johannes R. Schmidt, Janine Haupt, Sina Riemschneider, Christoph Kämpf, Dennis Löffler, Conny Blumert, Kristin Reiche, Ulrike Koehl, Stefan Kalkhof, Jörg Lehmann
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Immunology
Subjects:
aryl hydrocarbon receptor
macrophage activation
innate immunity
immunomodulation
transcriptomics
benzo[a]pyrene
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1156493/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1156493/full

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