Synthesis of Pyrimidine Conjugates with 4-(6-Amino-hexanoyl)-7,8-difluoro-3,4-dihydro-3-methyl-2<i>H</i>-[1,4]benzoxazine and Evaluation of Their Antiviral Activity

Synthesis of Pyrimidine Conjugates with 4-(6-Amino-hexanoyl)-7,8-difluoro-3,4-dihydro-3-methyl-2<i>H</i>-[1,4]benzoxazine and Evaluation of Their Antiviral Activity

A series of pyrimidine conjugates containing a fragment of racemic 7,8-difluoro-3,4-dihydro-3-methyl-2<i>H</i>-[1,4]benzoxazine and its (<i>S</i>)-enantiomer attached via a 6-aminohexanoyl fragment were synthesized by the reaction of nucleophilic substitution of chlorine in v...

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Bibliographic Details
Main Authors: Victor P. Krasnov, Vera V. Musiyak, Galina L. Levit, Dmitry A. Gruzdev, Valeriya L. Andronova, Georgii A. Galegov, Iana R. Orshanskaya, Ekaterina O. Sinegubova, Vladimir V. Zarubaev, Valery N. Charushin
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Molecules
Subjects:
pyrimidine
purine
7,8-difluoro-3,4-dihydro-3-methyl-2<i>H</i>-[1,4]benzoxazine
antiviral activity
HSV-1
influenza virus
Online Access:https://www.mdpi.com/1420-3049/27/13/4236

Internet

https://www.mdpi.com/1420-3049/27/13/4236

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