Activation of uroepithelial 5-HT4R inhibits mechanosensory activity of murine bladder afferent nerves

Serotonin (5-HT) is known to act via multiple 5-HT receptors at spinal and supraspinal levels to regulate micturition. However, the contribution of peripheral 5-HT and its receptors in bladder physiology and pathology is not very well understood, despite evidence showing expression of multiple 5-HT...

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Bibliographic Details
Main Authors: Yu Lu, Jie Li, Li Dong, Ping Luo, Guohua Zhang, Weifang Rong
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Physiology
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2022.990178/full