Tobacco smoke condensate-induced senescence in endothelial cells was ameliorated by colchicine treatment via suppression of NF-κB and MAPKs P38 and ERK pathways activation

Tobacco smoke condensate-induced senescence in endothelial cells was ameliorated by colchicine treatment via suppression of NF-κB and MAPKs P38 and ERK pathways activation

Abstract Smoking is the major cause of cardiovascular diseases and cancer. It induces oxidative stress, leading to DNA damage and cellular senescence. Senescent cells increase the expression and release of pro-inflammatory molecules and matrix metalloproteinase, which are known to play a vital role...

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Bibliographic Details
Main Authors: Dilaware Khan, Huakang Zhou, Jinliang You, Vera Annika Kaiser, Rajiv K Khajuria, Sajjad Muhammad
Format: Article
Language:English
Published: BMC 2024-04-01
Series:Cell Communication and Signaling
Subjects:
Tobacco smoke
HUVECs
NF-kB
MAPKs
Senescence
SASP factors
Online Access:https://doi.org/10.1186/s12964-024-01594-x

Internet

https://doi.org/10.1186/s12964-024-01594-x

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