Antagonism Between Saturated and Unsaturated Fatty Acids in ROS Mediated Lipotoxicity in Rat Insulin-Producing Cells

Antagonism Between Saturated and Unsaturated Fatty Acids in ROS Mediated Lipotoxicity in Rat Insulin-Producing Cells

Background/Aims: Elevated levels of non-esterified fatty acids (NEFAs) are under suspicion to mediate β-cell dysfunction and β-cell loss in type 2 diabetes, a phenomenon known as lipotoxicity. Whereas saturated fatty acids show a strong cytotoxic effect upon insulin-producing cells, unsaturated fatt...

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Bibliographic Details
Main Authors: Wiebke Gehrmann, Wiebke Würdemann, Thomas Plötz, Anne Jörns, Sigurd Lenzen, Matthias Elsner
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2015-05-01
Series:Cellular Physiology and Biochemistry
Subjects:
Lipotoxicity
Type 2 diabetes mellitus
Oxidative stress
Hydrogen peroxide
Peroxisome
Palmitic acid
Oleic acid
Online Access:http://www.karger.com/Article/FullText/430261

Internet

http://www.karger.com/Article/FullText/430261

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