Fibroblast growth factor receptor family mutations as a predictive biomarker for immune checkpoint inhibitors and its correlation with tumor immune microenvironment in melanoma

Fibroblast growth factor receptor family mutations as a predictive biomarker for immune checkpoint inhibitors and its correlation with tumor immune microenvironment in melanoma

BackgroundThe emergence of immune checkpoint inhibitors (ICIs) has significantly improved the clinical outcomes of patients with metastatic melanoma. However, survival benefits are only observed in a subset of patients. The fibroblast growth factor receptor (FGFR) family genes are frequently mutated...

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Bibliographic Details
Main Authors: Wengang Zhang, Handai Xia, Rui Yang, Yuqing Zhang, Qi Zheng, Xiaoling Shang, Ni Liu, Xinchun Ma, Chenxi Wei, Hang Chen, Xin Mu, Xiuwen Wang, Yanguo Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Immunology
Subjects:
FGFR mutations
immune checkpoint inhibitors
melanoma
biomarker
tumor immune microenvironment
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1030969/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2022.1030969/full

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