mTOR hyperactivity and RICTOR amplification as targets for personalized treatments in malignancies

mTOR hyperactivity and RICTOR amplification as targets for personalized treatments in malignancies

The increasing knowledge of molecular alterations in malignancies, including mutations and regulatory failures in the mTOR (mechanistic target of rapamycin) signaling pathway, highlights the importance of mTOR hyperactivity as a validated target in common and rare malignancies. This review summarise...

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Bibliographic Details
Main Authors: Dániel Sztankovics, Dorottya Moldvai, Gábor Petővári, Titanilla Dankó, Fatime Szalai, Risa Miyaura, Viktória Varga, Noémi Nagy, Gergő Papp, Judit Pápay, Ildikó Krencz, Anna Sebestyén
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-03-01
Series:Pathology and Oncology Research
Subjects:
mTOR
mTORC2 hyperactivity
RICTOR amplification
Rictor overexpression
malignancies
Online Access:https://www.por-journal.com/articles/10.3389/pore.2024.1611643/full

Internet

https://www.por-journal.com/articles/10.3389/pore.2024.1611643/full

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