Emerging Roles of SIRT5 in Metabolism, Cancer, and SARS-CoV-2 Infection

Emerging Roles of SIRT5 in Metabolism, Cancer, and SARS-CoV-2 Infection

Sirtuin 5 (SIRT5) is a predominantly mitochondrial enzyme catalyzing the removal of glutaryl, succinyl, malonyl, and acetyl groups from lysine residues through a NAD<sup>+</sup>-dependent deacylase mechanism. SIRT5 is an important regulator of cellular homeostasis and modulates the activ...

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Bibliographic Details
Main Authors: Emanuele Fabbrizi, Francesco Fiorentino, Vincenzo Carafa, Lucia Altucci, Antonello Mai, Dante Rotili
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Cells
Subjects:
SIRT5
sirtuins
HDACs
protein lysine desuccinylation
epigenetic
SIRT5 modulators
Online Access:https://www.mdpi.com/2073-4409/12/6/852

Internet

https://www.mdpi.com/2073-4409/12/6/852

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