Orchestration of energy metabolism and osteogenesis by Mg2+ facilitates low-dose BMP-2-driven regeneration

Orchestration of energy metabolism and osteogenesis by Mg2+ facilitates low-dose BMP-2-driven regeneration

The clinical application of bone morphogenetic protein-2 (BMP-2) is limited by several factors, including ineffectiveness at low doses and severe adverse effects at high doses. To address these efficacy and safety limitations, we explored whether orchestration of energy metabolism and osteogenesis b...

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Bibliographic Details
Main Authors: Sihan Lin, Shi Yin, Junfeng Shi, Guangzheng Yang, Xutao Wen, Wenjie Zhang, Mingliang Zhou, Xinquan Jiang
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2022-12-01
Series:Bioactive Materials
Subjects:
Biomaterials
Bone morphogenetic protein-2
Magnesium
Energy metabolism
Bone regeneration
Online Access:http://www.sciencedirect.com/science/article/pii/S2452199X22001396

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http://www.sciencedirect.com/science/article/pii/S2452199X22001396

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