Co-existing TP53 and ARID1A mutations promote aggressive endometrial tumorigenesis.

Co-existing TP53 and ARID1A mutations promote aggressive endometrial tumorigenesis.

TP53 and ARID1A are frequently mutated across cancer but rarely in the same primary tumor. Endometrial cancer has the highest TP53-ARID1A mutual exclusivity rate. However, the functional relationship between TP53 and ARID1A mutations in the endometrium has not been elucidated. We used genetically en...

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Bibliographic Details
Main Authors: Jake J Reske, Mike R Wilson, Jeanne Holladay, Rebecca A Siwicki, Hilary Skalski, Shannon Harkins, Marie Adams, John I Risinger, Galen Hostetter, Ken Lin, Ronald L Chandler
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-12-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.1009986

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https://doi.org/10.1371/journal.pgen.1009986

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