Chronic myocardial and coronary arterial effects of intracoronary supersaturated oxygen therapy in swine with normal and ischemic-reperfused myocardium
Abstract The study assessed chronic myocardial, coronary and systemic effects of intracoronary supersaturated oxygen (SSO2) therapy. Left anterior descending coronary arteries of 40 swine were stented and randomized to 90-min selective intracoronary infusion of SSO2 (pO2 760–1000 mmHg) or normoxemic...
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-04-01
|
| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-09776-8 |
| _version_ | 1819210116937809920 |
|---|---|
| author | Grzegorz L. Kaluza Jeffrey L. Creech Ariel Furer Maxwell E. Afari Krzysztof Milewski Geng-Hua Yi Yanping Cheng Gerard B. Conditt Jenn C. McGregor Donald Blum Serge D. Rousselle Juan F. Granada Daniel Burkhoff |
| author_facet | Grzegorz L. Kaluza Jeffrey L. Creech Ariel Furer Maxwell E. Afari Krzysztof Milewski Geng-Hua Yi Yanping Cheng Gerard B. Conditt Jenn C. McGregor Donald Blum Serge D. Rousselle Juan F. Granada Daniel Burkhoff |
| author_sort | Grzegorz L. Kaluza |
| collection | DOAJ |
| description | Abstract The study assessed chronic myocardial, coronary and systemic effects of intracoronary supersaturated oxygen (SSO2) therapy. Left anterior descending coronary arteries of 40 swine were stented and randomized to 90-min selective intracoronary infusion of SSO2 (pO2 760–1000 mmHg) or normoxemic saline. In 20 out of 40 animals, SSO2 delivery followed a 60-min balloon occlusion to induce myocardial infarction (MI). In both normal and MI models, intracoronary treatment with hyperoxemic SSO2 therapy showed no evidence of coronary thrombosis. There were no biologically relevant differences between treatments at either time point in regard to coronary intervention site healing and neointimal growth. No signs of any myocardial or systemic toxicity were observed after 7 or 30 days. A trend was observed toward reduced incidence of microscopic MI scars and reduced infarct size in histopathology, as well as toward better recovery of echocardiographically evaluated global and regional contractility at 30 days. No treatment related infarcts or thromboemboli were observed in the downstream organs. |
| first_indexed | 2024-12-23T06:06:04Z |
| format | Article |
| id | doaj.art-50d8ed28d44344bd9faa7572351d0009 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-23T06:06:04Z |
| publishDate | 2022-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-50d8ed28d44344bd9faa7572351d00092022-12-21T17:57:33ZengNature PortfolioScientific Reports2045-23222022-04-0112111210.1038/s41598-022-09776-8Chronic myocardial and coronary arterial effects of intracoronary supersaturated oxygen therapy in swine with normal and ischemic-reperfused myocardiumGrzegorz L. Kaluza0Jeffrey L. Creech1Ariel Furer2Maxwell E. Afari3Krzysztof Milewski4Geng-Hua Yi5Yanping Cheng6Gerard B. Conditt7Jenn C. McGregor8Donald Blum9Serge D. Rousselle10Juan F. Granada11Daniel Burkhoff12Skirball Center for Innovation, Cardiovascular Research FoundationZOLL TherOx, Inc.Sheba Tel HaShomer City of HealthMaine Medical CenterAmerican Heart of PolandSkirball Center for Innovation, Cardiovascular Research FoundationSkirball Center for Innovation, Cardiovascular Research FoundationSkirball Center for Innovation, Cardiovascular Research FoundationSkirball Center for Innovation, Cardiovascular Research FoundationZOLL TherOx, Inc.StageBioSkirball Center for Innovation, Cardiovascular Research FoundationSkirball Center for Innovation, Cardiovascular Research FoundationAbstract The study assessed chronic myocardial, coronary and systemic effects of intracoronary supersaturated oxygen (SSO2) therapy. Left anterior descending coronary arteries of 40 swine were stented and randomized to 90-min selective intracoronary infusion of SSO2 (pO2 760–1000 mmHg) or normoxemic saline. In 20 out of 40 animals, SSO2 delivery followed a 60-min balloon occlusion to induce myocardial infarction (MI). In both normal and MI models, intracoronary treatment with hyperoxemic SSO2 therapy showed no evidence of coronary thrombosis. There were no biologically relevant differences between treatments at either time point in regard to coronary intervention site healing and neointimal growth. No signs of any myocardial or systemic toxicity were observed after 7 or 30 days. A trend was observed toward reduced incidence of microscopic MI scars and reduced infarct size in histopathology, as well as toward better recovery of echocardiographically evaluated global and regional contractility at 30 days. No treatment related infarcts or thromboemboli were observed in the downstream organs.https://doi.org/10.1038/s41598-022-09776-8 |
| spellingShingle | Grzegorz L. Kaluza Jeffrey L. Creech Ariel Furer Maxwell E. Afari Krzysztof Milewski Geng-Hua Yi Yanping Cheng Gerard B. Conditt Jenn C. McGregor Donald Blum Serge D. Rousselle Juan F. Granada Daniel Burkhoff Chronic myocardial and coronary arterial effects of intracoronary supersaturated oxygen therapy in swine with normal and ischemic-reperfused myocardium Scientific Reports |
| title | Chronic myocardial and coronary arterial effects of intracoronary supersaturated oxygen therapy in swine with normal and ischemic-reperfused myocardium |
| title_full | Chronic myocardial and coronary arterial effects of intracoronary supersaturated oxygen therapy in swine with normal and ischemic-reperfused myocardium |
| title_fullStr | Chronic myocardial and coronary arterial effects of intracoronary supersaturated oxygen therapy in swine with normal and ischemic-reperfused myocardium |
| title_full_unstemmed | Chronic myocardial and coronary arterial effects of intracoronary supersaturated oxygen therapy in swine with normal and ischemic-reperfused myocardium |
| title_short | Chronic myocardial and coronary arterial effects of intracoronary supersaturated oxygen therapy in swine with normal and ischemic-reperfused myocardium |
| title_sort | chronic myocardial and coronary arterial effects of intracoronary supersaturated oxygen therapy in swine with normal and ischemic reperfused myocardium |
| url | https://doi.org/10.1038/s41598-022-09776-8 |
| work_keys_str_mv | AT grzegorzlkaluza chronicmyocardialandcoronaryarterialeffectsofintracoronarysupersaturatedoxygentherapyinswinewithnormalandischemicreperfusedmyocardium AT jeffreylcreech chronicmyocardialandcoronaryarterialeffectsofintracoronarysupersaturatedoxygentherapyinswinewithnormalandischemicreperfusedmyocardium AT arielfurer chronicmyocardialandcoronaryarterialeffectsofintracoronarysupersaturatedoxygentherapyinswinewithnormalandischemicreperfusedmyocardium AT maxwelleafari chronicmyocardialandcoronaryarterialeffectsofintracoronarysupersaturatedoxygentherapyinswinewithnormalandischemicreperfusedmyocardium AT krzysztofmilewski chronicmyocardialandcoronaryarterialeffectsofintracoronarysupersaturatedoxygentherapyinswinewithnormalandischemicreperfusedmyocardium AT genghuayi chronicmyocardialandcoronaryarterialeffectsofintracoronarysupersaturatedoxygentherapyinswinewithnormalandischemicreperfusedmyocardium AT yanpingcheng chronicmyocardialandcoronaryarterialeffectsofintracoronarysupersaturatedoxygentherapyinswinewithnormalandischemicreperfusedmyocardium AT gerardbconditt chronicmyocardialandcoronaryarterialeffectsofintracoronarysupersaturatedoxygentherapyinswinewithnormalandischemicreperfusedmyocardium AT jenncmcgregor chronicmyocardialandcoronaryarterialeffectsofintracoronarysupersaturatedoxygentherapyinswinewithnormalandischemicreperfusedmyocardium AT donaldblum chronicmyocardialandcoronaryarterialeffectsofintracoronarysupersaturatedoxygentherapyinswinewithnormalandischemicreperfusedmyocardium AT sergedrousselle chronicmyocardialandcoronaryarterialeffectsofintracoronarysupersaturatedoxygentherapyinswinewithnormalandischemicreperfusedmyocardium AT juanfgranada chronicmyocardialandcoronaryarterialeffectsofintracoronarysupersaturatedoxygentherapyinswinewithnormalandischemicreperfusedmyocardium AT danielburkhoff chronicmyocardialandcoronaryarterialeffectsofintracoronarysupersaturatedoxygentherapyinswinewithnormalandischemicreperfusedmyocardium |