Focused ultrasound on the substantia nigra enables safe neurotensin-polyplex nanoparticle-mediated gene delivery to dopaminergic neurons intranasally and by blood circulation

Focused ultrasound on the substantia nigra enables safe neurotensin-polyplex nanoparticle-mediated gene delivery to dopaminergic neurons intranasally and by blood circulation

Abstract Neurotensin-polyplex nanoparticles provide efficient gene transfection of nigral dopaminergic neurons when intracerebrally injected in preclinical trials of Parkinson’s disease because they do not cross the blood–brain barrier (BBB). Therefore, this study aimed to open BBB with focused ultr...

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Bibliographic Details
Main Authors: Juan U. Mascotte-Cruz, Arturo Vera, Lorenzo Leija, Francisco E. Lopez-Salas, Michael Gradzielski, Joachim Koetz, Bismark Gatica-García, C. P. Rodríguez-Oviedo, Irais E. Valenzuela-Arzeta, Lourdes Escobedo, David Reyes-Corona, ME. Gutierrez-Castillo, Minerva Maldonado-Berny, Armando J. Espadas-Alvarez, Carlos E. Orozco-Barrios, Daniel Martinez-Fong
Format: Article
Language:English
Published: Springer 2024-04-01
Series:Discover Nano
Subjects:
Transient neuroinflammation
Reversible neurodegeneration
Gene transfection
Motor behavior
Nanomedicine
Bionanotechnology
Online Access:https://doi.org/10.1186/s11671-024-04005-9

Internet

https://doi.org/10.1186/s11671-024-04005-9

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