Reprogramming of T cell‐derived small extracellular vesicles using IL2 surface engineering induces potent anti‐cancer effects through miRNA delivery

Reprogramming of T cell‐derived small extracellular vesicles using IL2 surface engineering induces potent anti‐cancer effects through miRNA delivery

Abstract T cell‐derived small extracellular vesicles (sEVs) exhibit anti‐cancer effects. However, their anti‐cancer potential should be reinforced to enhance clinical applicability. Herein, we generated interleukin‐2‐tethered sEVs (IL2‐sEVs) from engineered Jurkat T cells expressing IL2 at the plasm...

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Bibliographic Details
Main Authors: Dokyung Jung, Sanghee Shin, Sung‐Min Kang, Inseong Jung, Suyeon Ryu, Soojeong Noh, Sung‐Jin Choi, Jongwon Jeong, Beom Yong Lee, Kwang‐Soo Kim, Christine Seulki Kim, Jong Hyuk Yoon, Chan‐Hyeong Lee, Felicitas Bucher, Yong‐Nyun Kim, Sin‐Hyeog Im, Byoung‐Joon Song, Kyungmoo Yea, Moon‐Chang Baek
Format: Article
Language:English
Published: Wiley 2022-12-01
Series:Journal of Extracellular Vesicles
Subjects:
cancer
exosomal PD‐L1
interleukin‐2
PD‐L1
small extracellular vesicle
small extracellular vesicle engineering
Online Access:https://doi.org/10.1002/jev2.12287

Internet

https://doi.org/10.1002/jev2.12287

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