The efficacy of the benzimidazoles oxfendazole and flubendazole against Litomosoides sigmodontis is dependent on the adaptive and innate immune system

The efficacy of the benzimidazoles oxfendazole and flubendazole against Litomosoides sigmodontis is dependent on the adaptive and innate immune system

Filarial nematodes can cause debilitating diseases such as lymphatic filariasis and onchocerciasis. Oxfendazole (OXF) is one promising macrofilaricidal candidate with improved oral availability compared to flubendazole (FBZ), and OXF is currently under preparation for phase 2 clinical trials in fila...

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Bibliographic Details
Main Authors: Frederic Risch, Johanna F. Scheunemann, Julia J. Reichwald, Benjamin Lenz, Alexandra Ehrens, Joséphine Gal, Frédéric Fercoq, Marianne Koschel, Martina Fendler, Achim Hoerauf, Coralie Martin, Marc P. Hübner
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Microbiology
Subjects:
filariae
Litomosoides sigmodontis
oxfendazole
flubendazole
macrofilaricide
combination therapy
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2023.1213143/full

Internet

https://www.frontiersin.org/articles/10.3389/fmicb.2023.1213143/full

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