Intracellular IFN-γ and IL-4 levels of CD4 + and CD8 + T cells in the peripheral blood of naturally infected (Leishmania infantum) symptomatic dogs before and following a 4-week treatment with miltefosine and allopurinol: a double-blinded, controlled and cross-sectional study

Intracellular IFN-γ and IL-4 levels of CD4 + and CD8 + T cells in the peripheral blood of naturally infected (Leishmania infantum) symptomatic dogs before and following a 4-week treatment with miltefosine and allopurinol: a double-blinded, controlled and cross-sectional study

Abstract Background Canine leishmaniosis (CanL) is a systemic disease caused by the protozoan parasite Leishmania infantum with a wide spectrum of clinical signs, with cutaneous, ocular, renal and lymphoreactive conditions prevailing in the clinical setting. The immune system plays a pivotal role in...

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Bibliographic Details
Main Authors: Dimitrios T. Matralis, Alexander F. Koutinas, Ioanna E. Papadogiannaki, Elias G. Papadopoulos, Emmanouil I. Papadogiannakis
Format: Article
Language:English
Published: BMC 2023-01-01
Series:Acta Veterinaria Scandinavica
Subjects:
Canine leishmaniosis
CD4 + cells
CD8 + cells
Intracellular cytokines
Treatment
Online Access:https://doi.org/10.1186/s13028-023-00666-1

Internet

https://doi.org/10.1186/s13028-023-00666-1

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