Analysis of Dual Class I Histone Deacetylase and Lysine Demethylase Inhibitor Domatinostat (4SC-202) on Growth and Cellular and Genomic Landscape of Atypical Teratoid/Rhabdoid

Analysis of Dual Class I Histone Deacetylase and Lysine Demethylase Inhibitor Domatinostat (4SC-202) on Growth and Cellular and Genomic Landscape of Atypical Teratoid/Rhabdoid

Central nervous system atypical teratoid/rhabdoid tumors (ATRTs) are rare and aggressive tumors with a very poor prognosis. Current treatments for ATRT include resection of the tumor, followed by systemic chemotherapy and radiation therapy, which have toxic side effects for young children. Gene expr...

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Bibliographic Details
Main Authors: Mariah M. Hoffman, Jessica S. Zylla, Somshuvra Bhattacharya, Kristin Calar, Timothy W. Hartman, Ratan D. Bhardwaj, W. Keith Miskimins, Pilar de la Puente, Etienne Z. Gnimpieba, Shanta M. Messerli
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Cancers
Subjects:
atrt
4sc-202
domatinostat
cancer stem cell
scaffold
single-cell rna-sequencing
systems biology
Online Access:https://www.mdpi.com/2072-6694/12/3/756

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https://www.mdpi.com/2072-6694/12/3/756

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