Increasing quantitation in spatial single-cell metabolomics by using fluorescence as ground truth

Increasing quantitation in spatial single-cell metabolomics by using fluorescence as ground truth

Imaging mass spectrometry (MS) is becoming increasingly applied for single-cell analyses. Multiple methods for imaging MS-based single-cell metabolomics were proposed, including our recent method SpaceM. An important step in imaging MS-based single-cell metabolomics is the assignment of MS intensiti...

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Bibliographic Details
Main Authors: Martijn R. Molenaar, Mohammed Shahraz, Jeany Delafiori, Andreas Eisenbarth, Måns Ekelöf, Luca Rappez, Theodore Alexandrov
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Molecular Biosciences
Subjects:
spatial single-cell metabolomics
imaging mass spectrometry (imaging MS)
SpaceM
ion suppression
fluorescein diacetate (FDA)
pixel-cell deconvolution
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2022.1021889/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2022.1021889/full

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