Ets transcription factor GABP controls T cell homeostasis and immunity

Ets transcription factor GABP controls T cell homeostasis and immunity

T cells need to undergo rapid proliferation in response to antigenic stimulation. Here the authors show that the Ets family transcription factor GABP is required for T-cell homeostasis and response to infection by inducing Mcm3 and Mcm5 expression and enabling S-phase entry.

Bibliographic Details
Main Authors: Chong T. Luo, Hatice U. Osmanbeyoglu, Mytrang H. Do, Michael R. Bivona, Ahmed Toure, Davina Kang, Yuchen Xie, Christina S. Leslie, Ming O. Li
Format: Article
Language:English
Published: Nature Portfolio 2017-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-01020-6

Internet

https://doi.org/10.1038/s41467-017-01020-6

Similar Items